Difference between metoprolol tartrate metoprolol er

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Are you curious about the variance between metoprolol tartrate and metoprolol ER? Understanding these distinctions is crucial for managing your heart health effectively. Metoprolol tartrate is known for its immediate release, while metoprolol ER offers extended release for lasting benefits. Dive into the nuances and make an informed decision for your well-being.

Difference between metoprolol tartrate and metoprolol er

Metoprolol tartrate and metoprolol er are two different formulations of the same medication, metoprolol, which is a beta-blocker commonly used to treat high blood pressure, angina, and heart failure.

The main difference between metoprolol tartrate and metoprolol er lies in their release mechanism. Metoprolol tartrate is an immediate-release formulation, which means it is rapidly absorbed and starts working quickly after taking it. On the other hand, metoprolol er (extended-release) is designed to release the medication slowly over time, providing a longer duration of action and allowing for once-daily dosing.

Metoprolol Tartrate

Metoprolol Tartrate

Release Mechanism Immediate-release
Duration of Action Short-acting
Dosing Multiple times a day

Metoprolol ER (Extended-Release)

Release Mechanism Extended-release
Duration of Action Long-acting
Dosing Once daily

It is important to follow your doctor’s instructions regarding which formulation of metoprolol to take and how to take it to ensure the best treatment outcome for your condition.


Metoprolol is a beta-blocker medication commonly used to treat high blood pressure, angina, and heart failure. It works by blocking the action of certain natural chemicals in the body, such as adrenaline, which can cause the heart to beat faster and harder. By blocking these chemicals, metoprolol helps to lower blood pressure and reduce the workload on the heart.

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Metoprolol is also used to prevent migraine headaches and reduce the frequency of angina attacks. It is available in several different forms, including immediate-release tablets, extended-release tablets, and injectable solutions.

Overall, metoprolol is a widely prescribed medication that has been shown to be effective in managing various cardiovascular conditions. It is important to follow your healthcare provider’s instructions carefully when taking metoprolol to ensure you get the maximum benefit from the medication.

Dosage Forms

Metoprolol Tartrate: This medication is available in tablet form and is usually taken 2 to 4 times daily. The tablets come in various strengths, including 25 mg, 50 mg, and 100 mg.

Metoprolol ER (Extended-Release): Also available in tablet form, metoprolol ER is designed to release the medication slowly over time, providing a more consistent level of the drug in the body. This formulation is typically taken once a day and comes in strengths ranging from 25 mg to 200 mg.

Both forms of metoprolol are used to treat various cardiovascular conditions, but the choice of dosage form may depend on the specific needs of the patient, such as the required dosing frequency and desired duration of action.

Dosage forms

Metoprolol is available in various dosage forms to cater to different patient needs. The most common dosage forms include:


  • Immediate-release tablets: These tablets are typically taken multiple times a day and provide quick relief of symptoms.
  • Extended-release tablets: These tablets are designed to release the medication slowly over an extended period, allowing for once-daily dosing.


  • Extended-release capsules: Similar to the extended-release tablets, these capsules provide prolonged drug delivery, often requiring once-daily dosing.
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It is important to follow the prescribed dosage form and dosing schedule as advised by a healthcare professional to ensure optimal treatment outcomes.

Half-life and duration of action

Metoprolol tartrate has a half-life of about 3 to 7 hours, while metoprolol ER (extended-release) has a longer half-life of about 10 to 12 hours. This difference in half-life affects the duration of action of the two formulations.

Metoprolol tartrate is typically taken multiple times a day to maintain a consistent level of the medication in the bloodstream. On the other hand, metoprolol ER is formulated to release the medication slowly over time, allowing for once-daily dosing.

With metoprolol tartrate, the effects of the medication peak within 1 to 2 hours after taking a dose and last for about 24 hours. In contrast, metoprolol ER reaches peak effects within 3 to 4 hours and provides sustained blood pressure control for up to 24 hours.

The differences in half-life and duration of action between metoprolol tartrate and metoprolol ER allow for healthcare providers to tailor treatment plans to individual patient needs, taking into account factors such as dosing frequency and blood pressure control throughout the day.

Indications and usage

Metoprolol is commonly prescribed for the treatment of high blood pressure (hypertension) to help lower the risk of strokes, heart attacks, and kidney problems. It is also used to treat chest pain (angina) and to improve survival rate after a heart attack. In addition, metoprolol may be prescribed for the prevention of migraine headaches and to manage certain types of heart rhythm disorders, such as atrial fibrillation.

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Dosage and Administration

The dosage of metoprolol will vary depending on the condition being treated and the individual’s response to the medication. It is important to follow the dosing instructions provided by your healthcare provider. Metoprolol is usually taken by mouth with or without food, typically once or twice daily. Do not suddenly stop taking metoprolol without consulting your doctor, as this can lead to worsening symptoms or dangerous complications.

Side effects and contraindications

Side effects:

Common side effects of metoprolol include fatigue, dizziness, slow heartbeat, and lightheadedness. Some people may also experience shortness of breath, cold hands, and feet, or depression while taking metoprolol. It is important to contact your healthcare provider if you experience any severe side effects or symptoms.


Metoprolol is contraindicated in patients with a known hypersensitivity to the drug, those with certain heart conditions such as heart block or heart failure, and in patients with severe circulation problems. It should be used with caution in patients with asthma, diabetes, or thyroid disorders. Pregnant women should consult their healthcare provider before taking metoprolol as it may have adverse effects on the developing fetus.